Potentiation of α-adrenoceptor-mediated responses following chronic β-adrenoceptor stimulation in the rat heart
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منابع مشابه
CONTRACTIONS DUE TO α-ADRENOCEPTOR AGONISTS ARE MEDIATED BY α1-ADRENOCEPTORS IN RAT CAROTID ARTERY
Some large vessels have a mixed functional population of postjunctional α1- and α 2-adrenoceptors. The purpose of the work presented here was to investigate the population of postjunctional α -adrenoceptors in the rat isolated common carotid artelY Male Wi star rats were killed by overdose with pentobarbitone sodium, after which the left and right common carotid arteries were removed. Rings...
متن کاملInteraction of metabolic and respiratory acidosis with α and β-adrenoceptor stimulation in rat myocardium.
BACKGROUND The effects of acute respiratory versus metabolic acidosis on the myocardium and their consequences on adrenoceptor stimulation remain poorly described. We compared the effects of metabolic and respiratory acidosis on inotropy and lusitropy in rat myocardium and their effects on the responses to α- and β-adrenoceptor stimulations. METHODS The effects of acute respiratory and metabo...
متن کاملBeta-adrenoceptor stimulation attenuates the hypertrophic effect of alpha-adrenoceptor stimulation in adult rat ventricular cardiomyocytes.
OBJECTIVES The study investigated whether beta-adrenoceptor antagonists augment the hypertrophic response of cardiomyocytes evoked by norepinephrine. BACKGROUND In adult ventricular cardiomyocytes, stimulation of alpha- but not beta-adrenoceptors induces myocardial hypertrophy. Natural catecholamines, like norepinephrine, stimulate simultaneously alpha- and beta-adrenoceptors. We investigated...
متن کاملSUPPRESSION OF VLDL-TRIACYLGLYCEROL SECRETION B Y BOTH α AND β-ADRENOCEPTOR AGONISTS IN ISOLATED RAT HEPATOCYTES
The effects of alpha and beta-adrenergic stimulation on triacylglycerol secretion were investigated in isolated rat hepatocytes. Epinephrine within 3h of incubation suppressed triacylglycerol secretion by 35% and increased its cellular content by 18%. The inhibitory effect of epinephrine was abolished by inclusion of phentolamine and also prazosin but not with propranolol. Trifluoperazine c...
متن کاملINFLUENCE OF ENDO THELIUM REMOVAL AND LNAME ON RESPONSES OF RAT COMMON CAROTID ARTERY TO α-ADRENOCEPTOR AGONISTS
In this study we investigated the effects of endothelium removal and L-NAME on responses to α-adrenoceptor agonists. Male Wistar rats were killed by overdose with pentobarbitone sodium, after which the left and right common carotid arteries were removed. Rings of arteries 3-4 mm in length were cut from each vessel and then mounted in 10 mL isolated organ bath, bathed in Krebs maintained at ...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1993
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1993.tb12857.x